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49ers vs. Cardinals MNF: Open Thread, Picks

Get your MNF picks in!

NFL: Los Angeles Chargers at San Francisco 49ers Kyle Terada-USA TODAY Sports

A clash between the NFC West on primetime tonight as the San Francisco 49ers go head-to-head with the Arizona Cardinals in Mexico City.

This has been quickly judged as a one-sided affair as the Cardinals will be without their franchise quarterback, Kyler Murray. However, wide receiver DeAndre Hopkins is active.

The odds from DraftKings Sportsbook for tonight are rather reflective of Murray’s absence and the 49ers’ recent improvements as they enter on a two-game winning streak.


Spread: 49ers -10
Over/Under: 43
Moneyline: 49ers -435/ Cardinals +350

Check out DraftKings Sportsbook, the official sportsbook partner of SB Nation.


It’s a consensus pick kind of night with the Beatdown staff taking the 49ers to win this matchup.

Current Standings

  1. Kyle Barber: 99-61
  2. Spencer Schultz: 97-63
  3. Jake Louque, Frank Platko: 96-66

After a few dominant weeks that pulled the Beatdown readers into contention, an ugly 6-6 Sunday has them one game from breaking 90.

Beatdown Readers: 89-70

Make sure to pick the right one for tonight’s contest and get that 90.


Who will win?

This poll is closed

  • 100%
    (5 votes)
  • 0%
    (0 votes)
5 votes total Vote Now