Tony Mandarich was a Consensus All-American in 1988 and the Big Ten Offensive Lineman of the Year in 1988. His combine measures were unheard of and Sports Illustrated called him The Incredible Bulk in honor of his impressive body. Mandarich would be drafted second overall by the Green Bay Packers in 1989, a mistake that is made even worse when Hall of Famers Barry Sanders, Derrick Thomas, and Deion Sanders were taken right after. Mandarich would be on a holdout until a week before the 1989 regular season began and he would spend most of his rookie season on special teams. After three seasons of lackluster play, Mandarich would be released in 1992 with a non-football injury citation. In 2008 Mandarich admitted to using steroids in college and that he was addicted to painkillers and alcohol in the NFL.
Marinovich was raised by his father with the intent that he would grow up to become an NFL quarterback. He grew up with a strict diet and exercise regimen that his father imposed on him from the time he was one month old. He would get drafted 24th overall in the 1991 NFL Draft, nine spots ahead of eventual Hall of Fame quarterback Brett Favre. Marinovich's addiction to drugs would get him suspended frequently and he would get released by the Raiders during the final cut-down in 1993. He would never play in the NFL again, but would have a brief stint as a quarterback in the Canadian Football League and the Arena Football League between 1999-2001.
The Heisman runner-up was drafted third overall in 1994 and held out until he received a 7-year, $19.25 million contract. Shuler spent his career as a Redskin in a constant quarterback controversy with Gus Frerotte, who was also drafted by the Redskins in 1994, but in the seventh round. Shuler would start 18 games in his first two seasons, before getting benched in 1996 for Frerotte, who would go to the Pro Bowl. Shuler would get traded to the Saints in 1997 and then fall out of football in 1998. Frerotte would play football until 2008.
The 1995 Rose Bowl MVP would get drafted first overall in the 1995 NFL Draft by the Cincinnati Bengals, who traded up with the newly formed Carolina Panthers to draft him. Carter would suffer severe injuries that would cause him to miss 44 games during his five seasons as a Bengal. After brief stints with the Saints and Redskins, Carter was out of football in 2004.
Phillips would get drafted sixth overall in 1996 by the St. Louis Rams. However his frequent legal problems would cause him to get cut mid-season in 1997. After brief stints with the Dolphins and 49ers, Phillips would find himself out of football before the end of the 1999 season and would eventually land himself in prison. Pro Bowl running-back Eddie George would get picked 14th overall.
Druckenmiller was selected 26th overall in 1997 with the purpose of succeeding Steve Young one day. Druckenmiller lasted only two seasons with the 49ers before getting traded to the Miami Dolphins. The Dolphins would cut him before the 2000 season,and he would never get an NFL job again.
The San Diego Chargers would trade up to the number two spot to draft Ryan Leaf. Leaf's strong arm and linebacker toughness was supposed to make him the future for the San Diego Chargers, who needed a quarterback after scoring the fewest touchdowns during 1997. Leaf had a poor work ethic to the point where he would be found on the golf course while other quarterbacks were watching film. Leaf would be a turnover machine as a Charger and would get cut after the 2000 season. He is often referred to as the biggest bust in NFL history.
Couch won multiple SEC awards in 1998 and was a Consensus All-American. He was drafted first overall in 1999 by the reactivated Cleveland Browns. However Couch would struggle behind a hastily assembled Browns team that put him behind a makeshift offensive line. In his five season career Couch was inconsistent and injury prone. He was released in 2003, and despite two comeback attempts he never made it back into the NFL.
Smith started only 11 games as a college player at Oregon, but his excellent production and athleticism had the Bengals so enamored with him that they passed up Mike Ditka's offer of nine draft picks to take Smith third overall in 1999. Smith would never grasp the Bengals playbook, and would have only 17 starts in four seasons as a Bengal, and would get cut in 2002.
Underwood was selected 29th overall by the Vikings, but he would never play a down for them. Underwood walked out of camp on the first day and was released by the Vikings later that month. The Dolphins would pick him up, but he would struggle with focusing on football as he was too busy writing notes about the apocalypse.
He would get injured in the first preseason game. In September of 1999 he would get arrested for failing to pay child support. 24 hours later he would try to attempt suicide with a cutlass before shouting that he was unworthy of God. In 2000 the Cowboys, who had already handled a mentally unstable case before with Alonzo Spellman, signed Underwood to a two year contract. Underwood was decent as a reserve player, but after a second suicide attempt in January of 2001 and multiple missed practices, he was cut by the Cowboys and out of the NFL.
Yahoo Sports' Charles Robinson called Underwood one of the worst picks since the merger and his article stated that he missed most of his senior year and the Michigan State coaches warned scouts that he was too unstable to play in the NFL.
After a stellar career at Fresno State, David (not to be confused with younger brother and Oakland Raiders quarterback, Derek) Carr was selected first overall by the newly formed Houston Texans in 2002. Unfortunately Carr was prematurely thrust behind an offensive line that consisted of castoffs from NFL teams. Carr was the most sacked quarterback in 2002 with 76 sacks and in 2005 with 68 sacks. His 76 sacks taken in 2002 is the most sacks a quarterback has ever had to suffer in a single season. He would get cut after the 2006 season. During those five seasons as a Texan, Carr was sacked a mind-boggling 267 times. In comparison, Dan Marino was sacked 270 times over the course of his entire 17 seasons as a starter.
Gallery was selected second overall by the Oakland Raiders in 2004. Gallery was a turnstile at all five positions on the offensive line and never became the pillar of the franchise he was supposed to be. What makes matters worse is that Larry Fitzgerald and Philip Rivers were taken after Gallery.
Selected 22nd overall in the 2004 NFL Draft, Losman was the first quarterback taken by the Bills in the first round of the draft since Jim Kelly in 1983. Unlike Kelly, Losman would struggle with injuries and accuracy during his time as a Bill and would get replaced by Ryan Fitzpatrick after the 2008 season. Losman was the only bust out of the three quarterbacks taken in 2004.
After an excellent career at Texas, where he was a two-time Rose Bowl MVP, BCS Champion and Consensus All-American in 2005, Vince Young was selected third overall by the Tennessee Titans with the intention that he would replace the recently released Steve McNair. Young was an incredible athlete, however he would only score a 6 on the Wonderlic test. He would get a score of 16 on the retake. Young would struggle with turnovers during his first two seasons, but he would still make the Pro Bowl in 2006, and the Titans still made it to the playoffs in 2007. In 2008 he lost his job to an aged Kerry Collins after an injury and only regained it in the middle of 2009 after Collins was ineffective and the Titans had not won a single game. In 2010 Young would permanently lose his starting job for the Titans after a dispute with coach Jeff Fisher and he would spent the rest of his career trying to catch on elsewhere as a back-up.
After an excellent career at USC, Leinart was drafted tenth overall by the Arizona Cardinals. Leinart would end up losing his starting job to Kurt Warner and then to Derek Anderson after Kurt Warner retired following the 2009 season. Leinart would spend two years backing up Matt Schaub in Houston before falling out of the league.
Russell would start his career by holding out and missing training camp and the first week of the 2007 season until he was given a six-year $68 million contract. Russell would not become the Raiders full-time starter until the 2008 season. In November of 2009 Russell's poor play had him losing the starting job and he would never get it back. Russell was described as perpetually overweight and struggled with accuracy and with his work ethic. In May of 2010, Russell would get released by the Raiders and was not picked up by any NFL team.
The Browns would trade back into the first round of the 2007 NFL Draft to take Brady Quinn 22nd overall. Quinn would not start until Week 9 of the 2008 season. Quinn would only last two games during the 2008 season before going on injured reserve with a broken finger. In 2009 Quinn was part of a quarterback controversy along with Derek Anderson that continued until Quinn suffered a Lisfranc injury in Week 15 of the season. Quinn was traded to the Broncos in 2010 and would spend the next two seasons on the bench. He signed with the Chiefs in 2012 and had some action as a backup. He has not played a game since, but he was on a few teams rosters during the 2013 NFL season.
Gholston was drafted sixth overall in the 2008 NFL Draft. Despite having a $9 million contract escalator that would've been triggered if he had one measly sack, forced fumble, or fumble recovery, he would fail to do any of those things. ESPN shows that during his three seasons with the Jets, 600 players had at least one sack.
Drafted fourth overall by the Seattle Seahawks in 2009, Curry never lived up to his expectations, or proved that he was worth the $34 million guaranteed to him, the most money ever guaranteed to a non-quarterback rookie. He would permanently lose the starting job to K.J. Wright in the middle of the 2011 season. He would get traded to the Raiders in 2012 and would retire before the 2013 season.
Sam Bradford was drafted first overall in the 2010 NFL Draft. During his time as a starter the Rams never even made it to 8-8, as his injuries and mediocre play would hinder the team, despite all of the investments given to him through free agency and the draft.
Locker was inexplicably taken eighth overall, despite the fact that he had a terrible completion percentage and mediocre statistics in college. Locker spent most of his rookie season as a back-up and he would struggle with accuracy, consistency, and injuries for the next three seasons after becoming a starter in 2012. He would retire after the 2014 season.
The Browns would trade up with the Vikings (the team in the NFL who needed a running-back the least) to draft Trent Richardson third overall. After a mediocre 2012, Richardson was traded two games into the 2013 season for the Colts' first round pick. Richardson was one of the worst running-backs in the NFL, struggling with speed and his inability to hit the hole. He is currently an Oakland Raider.
Weeden was selected 22nd overall in 2012 and had a poor rookie season. In Week 8 of 2013 he was benched in favor of Jason Campbell. After the 2013 season he was cut and is currently Tony Romo's back-up in Dallas. He was drafted before Pro Bowl Quarterbacks Nick Foles and Russell Wilson. He's also older than most quarterbacks in the NFL, despite being in the NFL for a considerably shorter amount of time.