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Ravens pass rush vs. Saints offensive line
The Saints have had struggles on the interior offensive line this year. Unfortunately for Brees, Haloti Ngata is experiencing a renaissance this year, due in part to the emergence of Brandon Williams as a dominant young nose tackle. Timmy Jernigan is starting to heat up after being slowed by injury early in the season.
Will Hill vs. Jimmy Graham
This is the big matchup. It's an act of futility to run against the Ravens, and Marques Colston and Kenny Stills are struggling, while Brandin Cooks is out. From Dean Pees' remarks about Will Hill's ability, it's safe to say that Hill will be covering Graham.
Ravens run game vs. Saints defensive line
The Saints have one of the worst run defenses in the league. Justin Forsett and Lorenzo Taliaferro should have an easy time keeping Brees on the sideline.
Torrey Smith and Steve Smith vs. the Saints secondary
The Saints are one of the NFL's worst teams vs. the pass, and they're starting Marcus Ball or Jamarca Sanford at safety. The Ravens shouldn't have any trouble going deep.
Jacoby Jones vs. the Saints special teams
The last time Jones was in the Superdome, he put on a spectacular performance. Maybe the memories of the Super Bowl mixed with being in his hometown could give him a repeat.