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Seattle Seahawks (-5.5) at Arizona Cardinals
The Seahawks are rolling at 5-1 right now and don't appear to be slowing down. They won't get Percy Harvin back this week but his return is coming soon. But even without Harvin against a divisional foe, Seattle should get the job done. Prediction: Seahaws 31, Cardinals 21
New England Patriots (-4) at New York Jets
The Jets should have won Week 2's matchup and are now in a must-win situation. It's still unclear if tight end Rob Gronkowski will play. Without Gronkowski, the Patriots are certainly beatable. Prediction: Patriots 27, Jets 24
San Diego Chargers (-7.5) at Jacksonville Jaguars
The Chargers' offense is heating up, showing why Mike McCoy is highly regarded by his peers and why Norv Turner should have never been hired. The Jaguars were able to keep Denver from covering a 27-point spread last week. This is a much for favorable spread for bettors, even with the Chargers traveling east for a 1 p.m. game. Prediction: Chargers 27, Jaguars 17
Cincinnati Bengals at Detroit Lions (-2.5)
Both of these 4-2 teams need a win to help stay atop of their respective division. This game could feature two multi-purpose running backs (Reggie Bush and Gio Bernard) making big plays in both facets on offense. The Lions get the edge due to Matthew Stafford at quarterback. Prediction: Lions 34, Bengals 31
Buffalo Bills at Miami Dolphins (-7.5)
Coming off of a bye, the Dolphins should be well rested. The Bills are hurting. It's expected that Thad Lewis will be able to make another start this week after his injury late last week against Cincinnati. Call me crazy, but I like the young quarterback. Prediction: Bills 24, Dolphins 23
Chicago Bears at Washington Redskins (pick)
Even when the Redskins' defense steps up against a team like Dallas, special teams and offensive issues of their own let them down. The Bears, however, are reliant on forcing turnovers. Otherwise, they are susceptible on defense. Could the Redskins finally get a win over a worthwhile opponent? Prediction: Redskins 28, Bears 27
Dallas Cowboys at Philadelphia Eagles (-3)
Michael Vick's hamstring is still nagging him and he'll miss another start. But Nick Foles has impressed and tore up a Tampa Bay secondary last week that isn't that bad. Look for Foles to continue making plays while limiting mistakes within Chip Kelly's offense. Prediction: Eagles 34, Cowboys 27
St. Louis Rams at Carolina Panthers (-6)
The Rams are feeling pretty good about themselves after throttling the Texans 38-13. They'll look to carry that momentum in Carolina, where Cam Newton is coming off a big game of his own. Look for this one to be closer than expected, especially now that Zac Stacy is getting some good runs in for St. Louis. Prediction: Panthers 24, Rams 21
Tampa Bay Buccaneers at Atlanta Falcons (-7)
The Falcons are 1-4 and desperate for a win. They're a much better team than the record indicates. Therefore a home game against an abysmal Tampa Bay team self-imploding is something needed at this time. Look for the Falcons to win big. Prediction: Falcons 38, Buccaneers 17
Houston Texans at Kansas City Chiefs (-6)
Don't look now but the Chiefs appear to have the best defense in football. After sacking Terrelle Pryor 10 times last week, the Chiefs will be looking for more. To top it all off, the Texans are starting Case Keenum at quarterback. Prediction: Chiefs 34, Texans 20
San Francisco 49ers (-4) at Tennessee Titans
The Titans have been a decent team defensively but will have a lot of trouble slowing down Frank Gore and the 49ers' rushing attack. On top of that, it looks like Colin Kaepernick and Vernon Davis are continuing to build their chemistry together. Prediction: 49ers 27, Titans 17
Cleveland Browns at Green Bay Packers (-10)
The Packers seem to be too big of favorites after coming off a two-point win while losing Randall Cobb for a while. The Browns' Joe Haden is tough to throw against and the front seven has some young playmakers. The key for Cleveland will be whether Brandon Weeden can make some plays in the passing game. The Browns lose but not by more than 10. Prediction: Packers 31, Browns 23
Denver Broncos (-6.5) at Indianapolis Colts
Jim Irsay was incredibly dumb for acting like Peyton Manning didn't mean much to his organization. Really dumb. Never poke a sleeping tiger with a stick. Never agitate Peyton Manning the week you play him. Prediction: Broncos 45, Colts 24.
Minnesota Vikings at New York Giants (-3.5)
There was no way for the Monday Night Football folks to predict how bad this matchup would turn out to be before the season started. It's so bad you almost want to flip a coin to see who wins. The Giants are due, right? Prediction: Giants 27, Vikings 23