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New York Giants at Chicago Bears (-7.5)
The Giants are 0-5 and looking miserable. The Bears have dropped two in a row after a 3-0 start. But the Bears should be able to move the ball against a horrible Giants defense while forcing Eli Manning into some turnovers. Could the younger Manning's career be on the downswing? Prediction: Bears 30, Giants 20
Oakland Raiders at Kansas City Chiefs (-9)
The Chiefs have proved they're not a fluke with everyone waiting to see them take on the Broncos later this season. In the meantime, they'll force Terrelle Pryor's Raiders into some turnovers while managing the ball efficiently on offense. Prediction: Chiefs 31, Raiders 17
Philadelphia Eagles (-1.5) at Tampa Bay Buccaneers
The Bucs may be without Carl Nicks to a reoccurrence of MRSA in his foot. That just adds to the problems Tampa Bay has had this year. Philly gets a win on the road. Prediction: Eagles 27, Buccaneers 24
Detroit Lions (-2.5) at Cleveland Browns
There's still a chance Calvin Johnson sits out of this game as he has yet to participate much in practice. If Johnson is unable to go, the Browns will focus all of their attention on Reggie Bush in the backfield. This has the makings of a fourth straight win for the Browns. Prediction: Browns 34, Lions 27
Carolina Panthers at Minnesota Vikings (-2.5)
Which Panthers quarterback will show up this week? Will it be Good Cam Newton or Bad Cam Newton? My money's on Bad Cam Newton. Prediction: Vikings 21, Panthers 10
St. Louis Rams at Houston Texans (-7.5)
A lot of focus has been on how bad the Jaguars and Giants have been this year. The Rams have been pretty bad at times too. But going against the turnover prone Texans, could give them a confidence boost. Surprise of the week — the Rams keep this game close thanks to a couple of interceptions. But they don't win. Prediction: Texans 27, Rams 24
Pittsburgh Steelers at New York Jets (-2.5)
Coming off of a bye, the Steelers should be prepared for a Jets team working on a somewhat short week, due to their Monday Night Football win over Atlanta. But the Steelers aren't the same team we're used to seeing. The defense has had injuries and the offense can't move the ball. The Jets' ground game has fared well and the defense has been better than expected. Could it be? 0-5? Prediction: Jets 17, Steelers 14
Cincinnati Bengals (-7) at Buffalo Bills
I'm surprised this line isn't higher. Buffalo's starting a guy named Thad Lewis. It's going to be tough for Lewis to move the ball through the air against Cincinnati. Prediction: Bengals 27, Bills 10
Tennessee Titans at Seattle Seahawks (-13.5)
The Seahawks are a much better team when they play in front of the 12th Man. The Titans are in trouble with Ryan Fitzpatrick at quarterback. Seattle should be able to assert its will on the Titans by the third quarter. Prediction: Seahawks 34, Titans 16
Jacksonville Jaguars at Denver Broncos (-27.5)
Maybe the Cowboys drafted the blueprint on how to move the ball against the Broncos. Then again, that was the Cowboys. This is Jacksonville. But even then, a 27.5-point spread? Can't do it. Prediction: Broncos 45, Jaguars 20
Arizona Cardinals at San Francisco 49ers (-10.5)
Divisional games tend to be closer than you'd expect. The Cardinals have a fairly good defense with a great secondary. The Niners' offense has sputtered at times. Covering a 10.5-point spread seems a bit tough. Prediction: 49ers 27, Cardinals 21
New Orleans Saints at New England Patriots (-2.5)
New England is expected to welcome the return of tight end Rob Gronkowski to the lineup, which should open up the passing game for Tom Brady. But the Saints' defense has been stingy under new coordinator Rob Ryan. This game could wind up with a score lower than many expect. Prediction: Saints 24, Patriots 21
Washington Redskins at Dallas Cowboys (-5.5)
The Cowboys flashed their offensive firepower in a 51-48 loss to Denver last week. They now get a well-rested Redskins group that still possesses arguably the worst defense in football. Tony Romo should have a field day as Robert Griffin III plays catch-up throughout. Prediction: Cowboys 34, Redskins 24
Indianapolis Colts (-1.5) at San Diego Chargers
Andrew Luck is proving why he was the top overall pick a year ago. He's been playing out of his mind of late. The defense has made enough plays as well. The Colts should be able to pull this one out on the road. Prediction: Colts 27, Chargers 24