Miami Dolphins at Buffalo Bills (pick)
Tannehill is 0-2 at Buffalo and I expect that the Bills having an incredibly high attendance that will be celebrating the Bills staying in Buffalo as well as Jim Kelly being completely free of cancer should have the Bills confidence through the roof as they beat the Dolphins. Prediction: Bills 24, Dolphins 13
Jacksonville Jaguars at Washington Redskins (-6)
Washington was terrible against the Texans, while Jacksonville gave the Eagles fits for the first half. I expect that Jacksonville will give a lesser opponent fits for all three quarters in a low-scoring, ugly game. Prediction: Jaguars 15, Redskins 7
Dallas Cowboys at Tennessee Titans (-3.5)
The Titans have a nasty defensive line and Jake Locker looked elite vs. a depleted Chiefs defense. I expect that he'll put up a performance that is just as good if not better vs. a terrible Cowboys defense. Prediction: Titans 20, Cowboys 13
Arizona Cardinals (-2.5) at New York Giants
The Cardinals defense was excellent at pressuring Rivers even without Darnell Dockett, Daryl Washington, and Karlos Dansby. I expect them to have a good day against an abysmal Giants line, and make the day hard for an already struggling Giants offense. Prediction: Cardinals 27, Giants 0
New England Patriots (-6) at Minnesota Vikings
The Patriots should be going full cylinders on offense and defense, coming off of a rare Week 1 loss. I expect an Adrian Peterson-less Vikings to struggle heavily. Prediction: Patriots 21, Vikings 7
New Orleans Saints (-6.5) at Cleveland Browns
The Saints have Drew Brees and a stable of talented wide receivers and tight ends. The Browns have Brian Hoyer and walk-ons at wide receiver and Jordan Cameron is questionable. The Browns do have talented rushers and they have made the Saints look less spectacular, so at least they have that going for them, as well as the Saints struggles against non-dome road teams. Prediction: Saints 17, Browns 14
Atlanta Falcons at Cincinnati Bengals (-5.5)
The Falcons will likely be playing a tough Cincinnati defense without Jake Matthews at left tackle. I like the Bengals offense better than the Falcons defense and I think that the Bengals will be able to limit Roddy White and Julio Jones. Prediction: Bengals 28, Falcons 10
Detroit Lions at Carolina Panthers (-2.5)
The Panthers have a killer defensive line, which should give Matt Stafford trouble throughout the day with injuries taking a toll on the Lions offensive line. That being said, I think Stafford will be able to stay upright long enough to hit Megatron for a couple of scores in a battle of two No. 1 picks. Prediction: Lions 28, Panthers 27
St. Louis Rams at Tampa Bay Buccaneers (-6)
The Rams have a questionable quarterback situation and they're going to be without Chris Long for a couple of weeks. I expect that Tampa Bays' defense will give Shaun Hill/Austin Davis fits and that Tampa Bays' offense has a good game vs. a hobbled Rams defense. Prediction: Buccaneers 23, Rams 10
San Diego Chargers at Seattle Seahawks (-6)
The Seahawks are near invincible at home, Philip Rivers style of play goes plays right into the Seahawks hand, and the Chargers will be going with a back-up center. I expect that the Seahawks offense will exploit the Chargers defense and that Richard Sherman will take one back for six. Prediction: Seahawks 31, Chargers 7
Houston Texans (-3) at Oakland Raiders
The Texans are still an imperfect team. However the Raiders are more of an imperfect team, so I expect Houston to come out on top in a very ugly game. Prediction: Texans 14, Raiders 10
New York Jets at Green Bay Packers (-8)
The Jets secondary is their biggest weakness, which is going to make Aaron Rodgers happy, especially in Lambeau field, where Aaron Rodgers thrives. The Jets best chance is to run the ball often and sack Aaron Rodgers often. Prediction: Packers 38, Jets 24
Kansas City Chiefs at Denver Broncos (-12)
The Chiefs are missing two of their best defensive players and two of their starting offensive linemen. The Chiefs made Jake Locker look elite, so I don't have big hopes for them against a Hall of Famer in Peyton Manning. Prediction: Broncos 35, Chiefs 3
Chicago Bears at San Francisco 49ers (-6.5)
Chicago has traditionally struggled at San Francisco, losing games in horrific fashion. I expect that a Bears offense that's missing two offensive linemen and will have Brandon Marshall and Alshon Jeffery hobbled (if they play,they are questionable) to struggle against a San Francisco defense, even if it is hobbled. I expect a struggling Bears defense to struggle against the 49ers offense. Prediction: 49ers 41, Bears 10
Philadelphia Eagles at Indianapolis Colts (-3)
The Eagles have a bad defense, but the Colts' defense is worse. The Eagles can run the ball the Colts can not. This game should still be a shootout. Prediction: Eagles 42, Colts 41